COMPOUNDS AND METHODS FOR TREATING DISEASE

The invention provides compounds, compositions and methods for treating medical disorders, such as cancer, an autoimmune disorder, and/or a neurological disorder, and inhibiting LINE1 reverse transcriptase and/or HERV-K reverse transcriptase using a compound according to Formula I or a pharmaceutica...

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Bibliographic Details
Main Authors KAPELLER-LIBERMANN, Rosana, ROMERO, Donna L, BISACCHI, Gregory Stuart, ZALLER, Dennis, SAUNDERS, Oliver
Format Patent
LanguageEnglish
French
Published 26.10.2023
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Summary:The invention provides compounds, compositions and methods for treating medical disorders, such as cancer, an autoimmune disorder, and/or a neurological disorder, and inhibiting LINE1 reverse transcriptase and/or HERV-K reverse transcriptase using a compound according to Formula I or a pharmaceutically acceptable salt thereof, or a related compound provided herein. L'invention concerne des composés, des compositions et des méthodes de traitement de troubles médicaux, tels que le cancer, un trouble auto-immun et/ou un trouble neurologique, et l'inhibition de la transcriptase inverse LINE1 et/ou de la transcriptase inverse HERV-K à l'aide d'un composé selon la formule I ou d'un sel pharmaceutiquement acceptable de celui-ci, ou d'un composé associé selon l'invention.
Bibliography:Application Number: WO2023US64373