ANTI-GD2 ANTIBODIES, IMMUNOCONJUGATES AND THERAPEUTIC USES THEREOF

• Main Authors: MA, Jianguo, GROSS, Alec, SHAN, Min, DOTTERWEICH, Julia, MCKENNA, Sean D, ANDERL, Jan, RASCHE, Nicholas, AMENDT, Christiane, SLOOT, Willem
• Format: Patent
• Language: English; French
• Published: 14.09.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides antibodies which bind human GD2 protein, as well as isolated nucleic acids and host cells comprising a sequence encoding said antibodies. The invention also provides immunoconjugates comprising said antibodies linked to a growth-inhibitory agent, and pharmaceutical compositions comprising antibodies or immunoconjugates of the invention. The invention also provides use of the antibodies, immunoconjugates and pharmaceutical compositions of the invention for the treatment of cancer or for diagnostic purposes. L'invention concerne des anticorps qui se lient à la protéine GD2 humaine, ainsi que des acides nucléiques isolés et des cellules hôtes comprenant une séquence codant pour lesdits anticorps. L'invention concerne également des immunoconjugués comprenant lesdits anticorps liés à un agent inhibiteur de croissance, et des compositions pharmaceutiques comprenant des anticorps ou des immunoconjugués de l'invention. L'invention concerne également l'utilisation des anticorps, des immunoconjugués et des compositions pharmaceutiques de l'invention pour le traitement du cancer ou à des fins de diagnostic.