HUMAN ANTIBODIES AGAINST ACTIVATED PROTEIN C AND USES THEREOF

The present invention provides antibodies against activated protein C (APC). Certain disclosed antibodies inhibit the anticoagulant activity of APC while preserving its beneficial cytoprotective functions. The present invention also provides nucleic acids, vectors, and host cells for producing the a...

Full description

Saved in:
Bibliographic Details
Main Authors BAUZON, Maxine, ELLINGER, Philipp, FILARSKY, Katharina, SCHNEIDER, Douglas, WEBER, Ernst, MAHLERT, Christoph, SIM, Derek, TEBBE, Jan, HERMISTON, Terry, KENSCH, Oliver, CASTRO FERREIRA, Inês, MARTINS DA CUNHA ABECASIS, Bernardo
Format Patent
LanguageEnglish
French
Published 14.12.2023
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online AccessGet full text

Cover

More Information
Summary:The present invention provides antibodies against activated protein C (APC). Certain disclosed antibodies inhibit the anticoagulant activity of APC while preserving its beneficial cytoprotective functions. The present invention also provides nucleic acids, vectors, and host cells for producing the antibodies disclosed herein, as well as methods of using the antibodies to treat medical conditions such as bleeding, sepsis, and inflammation. La présente invention concerne des anticorps dirigés contre la protéine C activée (APC). Certains anticorps divulgués inhibent l'activité anticoagulante de l'APC tout en préservant ses fonctions cytoprotectrices bénéfiques. La présente invention concerne également des acides nucléiques, des vecteurs et des cellules hôtes destinés à produire les anticorps divulgués, ainsi que des méthodes d'utilisation des anticorps pour traiter des états médicaux tels que le saignement, le sepsis et l'inflammation.
Bibliography:Application Number: WO2023US63716