4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME

• Main Authors: CAO, Jingrong, SENTER, Timothy J, WANG, Haoxuan, BRODNEY, Michael A, ANGLE, Samantha, OLSEN, Jessica H, STONE, Steven D, DOLGIKH, Elena, NANTHAKUMAR, Suganthini, KRUEGER, Elaine B, GALE-DAY, Zachary, COME, Jon, DAKIN, Leslie A, SHIMIZU, Akira J
• Format: Patent
• Language: English; French
• Published: 17.08.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The disclosure provides at least one compound, tautomer, deuterated derivative, or pharmaceutically acceptable salt chosen from compounds of Formula I, tautomers thereof, deuterated derivatives of those compounds or tautomers, and pharmaceutically acceptable salts of any of the foregoing, compositions comprising the same, and methods of using the same, including uses in treating APOL1-mediated diseases, including pancreatic cancer, focal segmental glomerulosclerosis (FSGS), and/or non-diabetic kidney disease (NDKD). L'invention concerne au moins un composé, un tautomère, un deutéré, ou un sel pharmaceutiquement acceptable choisi parmi les composés de formule I, des tautomères de ceux-ci, des dérivés deutérés de ces composés ou tautomères, et des sels pharmaceutiquement acceptables de l'un quelconque de ceux-ci, des compositions les comprenant, et des procédés d'utilisation de ceux-ci, comprenant des utilisations dans le traitement de maladies médiées par APOL1, notamment le cancer du pancréas, la glomérulosclérose segmentaire focale (FSGS), et/ou une maladie rénale non diabétique (NDKD).