ANTIMALARIAL HEXAHYDROPYRIMIDINE ANALOGUES

A series of 2-imino-6-methylhexahydropyrimidin-4-one derivatives, substituted in the 6-position by an arylphenyl or heteroarylphenyl moiety, being potent inhibitors of the growth and propagation of the Plasmodium falciparum parasite in human blood, are beneficial as pharmaceutical agents, especially...

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Main Authors VIDLER, Lewis Robin, TAYLOR, Richard David, SAKATA, Komei, BRUFFAERTS, Jeffrey, STASI, Luigi Piero, XUAN, Mengyang, DE HARO GARCIA, Teresa, LOWE, Martin Alexander
Format Patent
LanguageEnglish
French
Published 17.08.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A series of 2-imino-6-methylhexahydropyrimidin-4-one derivatives, substituted in the 6-position by an arylphenyl or heteroarylphenyl moiety, being potent inhibitors of the growth and propagation of the Plasmodium falciparum parasite in human blood, are beneficial as pharmaceutical agents, especially in the treatment of malaria. Une série de dérivés de 2-imino-6-méthylhexahydropyrimidin-4-one, substitués en position 6 par une fraction arylphényle ou hétéroarylphényle, étant des inhibiteurs puissants de la croissance et de la propagation du parasite Plasmodium falciparum dans le sang humain, sont bénéfiques en tant qu'agents pharmaceutiques, en particulier dans le traitement du paludisme.
Bibliography:Application Number: WO2023EP52674