MAGNESIUM DIACETATE X 4H 2O AND/OR MAGNESIUM DICHLORIDE X 6H 2O AND/OR MAGNESIUM SULFATE X 7H 2O AND/OR DISODIUM SULFATE X 10 H 2O AND/OR SODIUM THIOSULFATE X 5H 2O AND/OR NA 3PO 4 X 12 H 2O AND/OR NA 2HPO 4 X 12H 2O/7H 2O AND/OR SODIUM ACETATE X 3H 2O AS GRANULATING AID

• Main Authors: GRUENSTEIN, Elisabeth, GUTH, Felicitas, CECH, Thorsten, RIES, Lukas, KOLTER, Karl
• Format: Patent
• Language: English; French
• Published: 10.08.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to a powder mixture for the preparation of a granulate comprising as constituent at least a filler or at least an active ingredient or both and as granulation aid Magnesium diacetate x 4H2O and/or Magnesium dichloride x 6H2O and/or Magnesium sulfate x 7H2O and/or Disodium sulfate xH2O and/or Sodium thiosulfate x 5H2O and/or Na3PO4 x 12 H2O and/or Na2HPO4 x 12H2O/7H2O and/or Sodium acetate x 3H2O. Optionally constituents of the powder mixture to be granulated are binders, disintegrants and further customary auxiliaries. It was an object of the present invention to provide a powder mixture which can be granulated without adding a liquid but where the water for the granulation is released in-situ from Magnesium diacetate x 4H2O and/or Magnesium dichloride x 6H2O and/or Magnesium sulfate x 7H2O and/or Disodium sulfate xH2O and/or Sodium thiosulfate x 5H2O and/or Na3PO4 x 12 H2O and/or Na2HPO4 x 12H2O/7H2O and/or Sodium acetate x 3H2O. An additional drying step is not required. La présente invention concerne un mélange pulvérulent pour la préparation d'un granulat comprenant, comme constituant, au moins une charge ou au moins un principe actif ou les deux et, comme adjuvant de granulation, du magnésium diacétate X 4H2O et/ou du dichlorure de magnésium x 6H2O et/ou du sulfate de magnésium x 7H2O et/ou du sulfate disodique xH2O et/ou du thiosulfate de sodium x 5H2O et/ou du Na3PO4 x 12 H2O et/ou du Na2HPO4 x 12H2O/7H2O et/ou de l'acétate de sodium x 3H2O. Éventuellement, des constituants du mélange pulvérulent sont des liants, des agents désintégrants et d'autres agents auxiliaires habituels. Un objet de la présente invention est de fournir un mélange pulvérulent qui peut être granulé sans ajouter de liquide mais où l'eau pour la granulation est libérée in situ à partir de diacétate de magnésium x 4H2O et/ou Magnesium dichloride x 6H2O and/or Magnesium sulfate x 7H2O et/ou Disodium sulfate xH2O et/ou Sodium thiosulfate x 5H2O et/ou Na3PO4 x 12 H2O and/or Na2HPO4 x 12H2O/7H2O et/ou Sodium acetate x 3H2O. Une étape de séchage supplémentaire n'est pas nécessaire.