MUC1 BINDING MOLECULE AND APPLICATION THEREOF

• Main Authors: QIAN, Qijun, CAI, Xianghai, SUN, Yan, ZHU, Weimin
• Format: Patent
• Language: Chinese; English; French
• Published: 03.08.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

The present invention relates to an MUC1 binding molecule and the application thereof. Specifically provided is an MUC1 binding molecule. The MUC1 binding molecule contains an anti-MUC1 single-domain antibody, and complementarity-determining regions (CDR) of the single-domain antibody include a CDR1, a CDR2 and a CDR3, wherein the CDR1 comprises a sequence as shown in SEQ ID NO: 1, the CDR2 comprises a sequence as shown in SEQ ID NO: 2, and the CDR3 comprises a sequence as shown in SEQ ID NO: 3. The MUC1 binding molecule can be bound to MUC1 in a high-specificity manner, and exhibits high affinity and a high biological activity. La présente invention concerne une molécule de liaison à MUC1 et son utilisation. L'invention concerne en particulier une molécule de liaison à MUC1. La molécule de liaison à MUC1 contient un anticorps à domaine unique anti-MUC1, et des régions déterminant la complémentarité (CDR) de l'anticorps à domaine unique comprennent une CDR1, une CDR2 et une CDR3, la CDR1 comprenant une séquen