NANOBODY-DRUG ADDUCTS AND USES THEREOF

Provided herein are conjugate molecules comprising an antibody or antibody fragment capable of binding polyclonal immunoglobulins within a subject. Such conjugates are useful for recruiting immune cells of the subject to one or more cell types that are targeted by the conjugate. Also provided herein...

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Bibliographic Details
Main Authors PISHESHA, Novalia, PLOEGH, Hidde, VERHAAR, Elisha, LIU, Xin
Format Patent
LanguageEnglish
French
Published 27.07.2023
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Provided herein are conjugate molecules comprising an antibody or antibody fragment capable of binding polyclonal immunoglobulins within a subject. Such conjugates are useful for recruiting immune cells of the subject to one or more cell types that are targeted by the conjugate. Also provided herein are compositions comprising the conjugates, including pharmaceutical compositions that may be administered to a subject, for such a purpose as to treat or prevent a disease. La présente invention concerne des molécules conjuguées comprenant un anticorps ou un fragment d'anticorps capable de se lier à des immunoglobulines polyclonales chez un sujet. De tels conjugués sont utiles pour recruter des cellules immunitaires du sujet à un ou plusieurs types de cellules qui sont ciblés par le conjugué. La présente invention concerne également des compositions comprenant les conjugués, y compris des compositions pharmaceutiques qui peuvent être administrées à un sujet, à des fins de traitement ou de prévention d'une maladie.
Bibliography:Application Number: WO2023US60893