METHODS OF IMAGE-GUIDED RESECTION OF TARGET TISSUES AND IMAGING DEVICES FOR PRACTICING SAME

Provided are methods of image-guided resection of a target tissue from a subject. In some embodiments, the methods comprise administering to the subject a conjugate comprising erbium-based rare-earth nanoparticles (ErNPs) conjugated to a targeting moiety that targets the ErNPs to the target tissue,...

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Bibliographic Details
Main Authors DAI, Hongjie, WANG, Feifei
Format Patent
LanguageEnglish
French
Published 27.07.2023
Subjects
CALCULATING
COMPUTER SYSTEMS BASED ON SPECIFIC COMPUTATIONAL MODELS
COMPUTING
COUNTING
IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
PHYSICS
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Summary:Provided are methods of image-guided resection of a target tissue from a subject. In some embodiments, the methods comprise administering to the subject a conjugate comprising erbium-based rare-earth nanoparticles (ErNPs) conjugated to a targeting moiety that targets the ErNPs to the target tissue, imaging the target tissue by NIR-llb imaging, and resecting the target tissue guided by the NIR-llb imaging. Also provided are portable imagers adapted for simultaneous color and NIR-II imaging. L'invention concerne des procédés de résection guidée par image d'un tissu cible d'un sujet. Dans certains modes de réalisation, les procédés comprennent l'administration au sujet d'un conjugué comprenant des nanoparticules de terres rares à base d'erbium (ErNP) conjuguées à une fraction de ciblage qui cible les ErNP sur le tissu cible, l'imagerie du tissu cible par imagerie dans le NIR-IIb, et la résection du tissu cible guidée par l'imagerie dans le NIR-IIb. L'invention concerne également des imageurs portables conçus pour une imagerie simultanée en couleurs et dans le NIR-II.
Bibliography:Application Number: WO2023US11069