MODULATORS OF A POTASSIUM CHANNEL AND OF TRPV1 CHANNEL AND USES THEREOF
Compounds represented by Formula I: (I) wherein A, B, W, V, Z, Ra, Rb, n and m are as defined in the instant specification, or by Formula la, lb, III, IV or V, as defined in the instant specification, and uses thereof in modulating an activity of a voltage-dependent potassium channel and/or a TRPV1...
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Main Authors | , , , |
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Format | Patent |
Language | English French |
Published |
27.07.2023
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Abstract | Compounds represented by Formula I: (I) wherein A, B, W, V, Z, Ra, Rb, n and m are as defined in the instant specification, or by Formula la, lb, III, IV or V, as defined in the instant specification, and uses thereof in modulating an activity of a voltage-dependent potassium channel and/or a TRPV1 channel and in treating a medical condition associated with an activity of these channels, such as medical conditions associated with neuronal hyper-excitability, are provided.
L'invention concerne des composés représentés par la formule I : (I) dans laquelle A, B, W, V, Z, Ra, Rb, n et m sont tels que définis dans la présente spécification, ou par la formule la, lb, III, IV ou V, tels que définis dans la présente spécification, et leurs utilisations dans la modulation de l'activité d'un canal potassique dépendant de la tension et/ou d'un canal TRPV1 et dans le traitement d'un état médical associé à une activité de ces canaux, tels que des états médicaux associés à une hyper-excitabilité neuronale. |
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AbstractList | Compounds represented by Formula I: (I) wherein A, B, W, V, Z, Ra, Rb, n and m are as defined in the instant specification, or by Formula la, lb, III, IV or V, as defined in the instant specification, and uses thereof in modulating an activity of a voltage-dependent potassium channel and/or a TRPV1 channel and in treating a medical condition associated with an activity of these channels, such as medical conditions associated with neuronal hyper-excitability, are provided.
L'invention concerne des composés représentés par la formule I : (I) dans laquelle A, B, W, V, Z, Ra, Rb, n et m sont tels que définis dans la présente spécification, ou par la formule la, lb, III, IV ou V, tels que définis dans la présente spécification, et leurs utilisations dans la modulation de l'activité d'un canal potassique dépendant de la tension et/ou d'un canal TRPV1 et dans le traitement d'un état médical associé à une activité de ces canaux, tels que des états médicaux associés à une hyper-excitabilité neuronale. |
Author | SILBERMAN, Alon BROWN, Alan Daniel BELINSON, Haim RAVEH, Adi |
Author_xml | – fullname: BELINSON, Haim – fullname: RAVEH, Adi – fullname: SILBERMAN, Alon – fullname: BROWN, Alan Daniel |
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DocumentTitleAlternate | MODULATEURS D'UN CANAL POTASSIQUE ET D'UN CANAL TRPV1 ET LEURS UTILISATIONS |
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RelatedCompanies | BSENSE BIO THERAPEUTICS LTD |
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Snippet | Compounds represented by Formula I: (I) wherein A, B, W, V, Z, Ra, Rb, n and m are as defined in the instant specification, or by Formula la, lb, III, IV or V,... |
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Title | MODULATORS OF A POTASSIUM CHANNEL AND OF TRPV1 CHANNEL AND USES THEREOF |
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