MODULATORS OF A POTASSIUM CHANNEL AND OF TRPV1 CHANNEL AND USES THEREOF

Compounds represented by Formula I: (I) wherein A, B, W, V, Z, Ra, Rb, n and m are as defined in the instant specification, or by Formula la, lb, III, IV or V, as defined in the instant specification, and uses thereof in modulating an activity of a voltage-dependent potassium channel and/or a TRPV1...

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Bibliographic Details
Main Authors BELINSON, Haim, RAVEH, Adi, SILBERMAN, Alon, BROWN, Alan Daniel
Format Patent
LanguageEnglish
French
Published 27.07.2023
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds represented by Formula I: (I) wherein A, B, W, V, Z, Ra, Rb, n and m are as defined in the instant specification, or by Formula la, lb, III, IV or V, as defined in the instant specification, and uses thereof in modulating an activity of a voltage-dependent potassium channel and/or a TRPV1 channel and in treating a medical condition associated with an activity of these channels, such as medical conditions associated with neuronal hyper-excitability, are provided. L'invention concerne des composés représentés par la formule I : (I) dans laquelle A, B, W, V, Z, Ra, Rb, n et m sont tels que définis dans la présente spécification, ou par la formule la, lb, III, IV ou V, tels que définis dans la présente spécification, et leurs utilisations dans la modulation de l'activité d'un canal potassique dépendant de la tension et/ou d'un canal TRPV1 et dans le traitement d'un état médical associé à une activité de ces canaux, tels que des états médicaux associés à une hyper-excitabilité neuronale.
Bibliography:Application Number: WO2023IL50058