MERCAPTOPYRIMIDINE COMPOUNDS THAT INHIBIT NONHOMOLOGOUS END JOINING AND METHODS THEREOF

The present disclosure provides a compound of Formula I, its stereoisomers, intermediates, and pharmaceutically acceptable salts thereof, capable of inhibiting DNA Ligase IV enzyme activity and nonhomologous end joining (NHEJ). The present disclosure also provides a process for preparing the compoun...

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Main Authors MANTELINGU, Kempegowda, RAY, Ujjayinee, RANGAPPA, Kanchugarakoppal S, SHARMA, Shivangi, GOPINATHA, Vindya K, RAGHAVAN, Sathees C
Format Patent
LanguageEnglish
French
Published 06.07.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present disclosure provides a compound of Formula I, its stereoisomers, intermediates, and pharmaceutically acceptable salts thereof, capable of inhibiting DNA Ligase IV enzyme activity and nonhomologous end joining (NHEJ). The present disclosure also provides a process for preparing the compounds of Formula I and methods thereof. La présente invention concerne un composé de formule I, ses stéréoisomères, intermédiaires et sels pharmaceutiquement acceptables, capables d'inhiber l'activité enzymatique de la ligase IV de l'ADN et la jonction d'extrémités non homologues (NHEJ). La présente invention concerne également un procédé de préparation des composés de formule I et des procédés associés.
Bibliography:Application Number: WO2022IN51147