TISSUE-SPECIFIC MANGANESE BASED MRI CONTRAST AGENTS

A tissue-specific manganese based magnetic resonance imaging (MRI) agent includes the formula: wherein T includes at least one cell specific or tissue specific targeting moiety; C includes at least one pyclen based chelating agent complexed with a Mn ion, and L includes at least one optional linker...

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Bibliographic Details
Main Authors QIN, Jing-Can, LU, Zheng-Rong, HALL, Ryan
Format Patent
LanguageEnglish
French
Published 29.06.2023
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:A tissue-specific manganese based magnetic resonance imaging (MRI) agent includes the formula: wherein T includes at least one cell specific or tissue specific targeting moiety; C includes at least one pyclen based chelating agent complexed with a Mn ion, and L includes at least one optional linker that covalently links the at least one targeting moiety to the at least one chelating agent. L'invention concerne un agent d'imagerie par résonance magnétique (IRM) à base de manganèse spécifique de tissu représenté par la formule : dans laquelle T comprend au moins une fraction de ciblage spécifique de cellule ou spécifique de tissu ; C comprend au moins un agent chélatant à base de pyclène complexé avec un ion Mn, et L comprend au moins un lieur facultatif qui relie de manière covalente ladite au moins une fraction de ciblage audit au moins un agent chélatant.
Bibliography:Application Number: WO2022US81985