SUBSTITUTED THIAZOLIDINEDIONE DERIVATIVE COMPOUND, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER, COMPRISING SAME

• Main Authors: PARK, Jong Min, KIM, Jun-Kyum, MIN, Ju-sik, LEE, Su-Jeong, KIM, Sang Bum, KIM, Sung Jin, CHOI, Jia, MIN, Kyungim, KIM, Dong-Hyun, KIM, Jina, PARK, Jeong-Eun, JEONG, Minseon, CHOI, Hyo-Jung, LEE, Sungwoo, KIM, Eun-Jung, CHO, Sung Jin, LIM, Ji-youn, HAM, Seok Won, KIM, Nayeon, KWON, Oh-Bin, PARK, Cheol-Kyu, KIM, Suhui, JEONG, Hyeon Ju, CHIN, Jungwook, KWON, Sugyeong, AN, Hongchan, HWANG, Ji Sun, PARK, Min Gi, HWANG, Hayoung, JUNG, Kyung Jin
• Format: Patent
• Language: English; French; Korean
• Published: 29.06.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to: a substituted thiazolidinedione derivative compound having a novel structure acting as a sterol regulatory element-binding protein-1 (SREBP1) inhibitor, a hydrate thereof, or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition for preventing or treating cancer, comprising same as an active ingredient. La présente invention concerne : un composé dérivé de thiazolidinedione substitué ayant une nouvelle structure agissant en tant qu'inhibiteur de protéine-1 de liaison à un élément régulateur de stérol (SREBP1), un hydrate de celui-ci, ou un sel pharmaceutiquement acceptable de celui-ci ; et une composition pharmaceutique pour prévenir ou traiter le cancer, le comprenant en tant que principe actif. 본 발명은 SREBP1(sterol regulatory element-binding protein-1) 저해제로 작용하는 신규 구조의 치환된 티아졸리딘디온 유도체 화합물, 이의 수화물 또는 이의 약학적으로 허용가능한 염 및 이를 유효성분으로 이를 포함하는 암의 예방 또는 치료용 약학적 조성물에 관한 것이다.