IMMUNOEVASIVE ANTI-TUMOR ADENOVIRUS

• Main Authors: KIM, Mi Soon, LEE, Wan, UM, Ki Hwan, YOO, Jung Ki, CHOI, Jin Woo
• Format: Patent
• Language: English; French; Korean
• Published: 29.06.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present invention relates to an anti-tumor adenovirus that can evade the in-vivo immune system. The adenovirus having high ability to kill tumor of the present invention, by comprising a nucleic acid encoding a transferrin binding moiety, has significantly increased effects of infecting and killing tumor cells, exhibits an increase in binding with transferrin to thereby evade in-vivo immune responses, leading to an increase in plasma half-life, is specifically delivered to cancer cells to produce systemic therapeutic effects, and can be topically delivered and has excellent selectivity, resulting in a remarkable effect in anti-tumor efficacy and, therefore, the adenovirus can be advantageously used as an anticancer composition or anticancer adjuvant in various types of cancer. La présente invention concerne un adénovirus anti-tumoral pouvant échapper au système immunitaire in vivo. L'adénovirus ayant une forte capacité de destruction des tumeurs de la présente invention, étant donné qu'il comprend un acide nucléique codant pour une fraction de liaison à la transferrine, possède des effets considérablement accrus d'infection et de destruction des cellules tumorales, présente une augmentation de la liaison avec la transferrine pour échapper ainsi aux réponses immunitaires in vivo, conduisant à une augmentation de la demi-vie plasmatique, est spécifiquement administré aux cellules cancéreuses pour produire des effets thérapeutiques systémiques, et peut être administré par voie topique et possède une excellente sélectivité, ce qui entraîne un effet remarquable dans l'efficacité anti-tumorale et, par conséquent, l'adénovirus peut être avantageusement utilisé comme composition anticancéreuse ou adjuvant anticancéreux dans divers types de cancer. 본 발명은 생체 내 면역 체계를 회피할 수 있는 항종양 아데노바이러스에 관한 것으로, 본 발명의 종양살상능이 높은 아데노바이러스는 트랜스페린 바인딩 모이어티를 코딩하는 핵산을 포함함으로써, 종양 세포 감염 및 사멸 효과가 현저히 증가하였으며, 트랜스페린과의 결합이 증가하므로, 이로 인해, 체내 면역 반응을 회피하여 혈장 반감기가 증가하고, 암세포에 특이적으로 전달되어 전신 치료 효과가 있으며, 국소 전달이 가능하고, 선택성이 뛰어나 항-종양 효능이 현저한 효과를 나타내, 다양한 암종에 항암용 조성물 또는 항암보조제로서 유용하게 이용될 수 있다.