8-AZA QUINAZOLINES AS BRAIN-PENETRANT SOS1-INHIBITORS

• Main Authors: MUELLER, Stephan Georg, WUNBERG, Tobias, GIOVANNINI, Riccardo, HEINE, Niklas, HOHN, Christoph, RAMHARTER, Juergen
• Format: Patent
• Language: English; French
• Published: 29.06.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to small molecules capable of inhibiting SOS1 (Son of Sevenless) and their salts. Specifically, the present invention relates to heterocyclic compounds of general formula (I) or salts thereof wherein A, X, R1, R2, R3 have one of the meanings as indicated in the specification. Furthermore, the invention relates to pharmaceutical compositions and combinations comprising these compounds, as well as their use in methods for the treatment of diseases associated with or modulated by SOS1. La présente invention concerne de petites molécules pouvant inhiber SOS1 (Son of Sevenless) et leurs sels. En particulier, la présente invention concerne des composés hétérocycliques de formule générale (I) ou des sels de ceux-ci, A, X, R1, R2, R3 ayant l'une des significations indiquées dans la description. En outre, l'invention concerne des compositions pharmaceutiques et des combinaisons comprenant ces composés, ainsi que leur utilisation dans des méthodes pour le traitement de maladies associées à ou modulées par SOS1.