COMPOUND CONTAINING BIS(AZANYLYLIDENE) SULFONYL STRUCTURE AND USE THEREOF IN MEDICINE

• Main Authors: HU, Xiao, ZHANG, Xiaodong, TANG, Jun, WANG, Zao, LI, Jianzong, WANG, Jing, SHAO, Tao, ZHOU, Ruijie, TANG, Yuanqing, WANG, Yeye, ZHAO, Shuchun
• Format: Patent
• Language: Chinese; English; French
• Published: 29.06.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

A compound containing a bis(azanylylidene) sulfonyl structure of formula (I) as a PKR agonist and/or USP9X inhibitor, which can be used for treating related diseases mediated and regulated by PKR and USP9X, wherein the related diseases comprise, but are not limited to: sickle-cell anemia, β-thalassemia, hereditary non-spherocytic hemolytic anemia, hemolytic anemia, hereditary spherocytosis, hereditary elliptocytosis, abetalipoproteinemia, paroxysmal nocturnal hemoglobinuria, acquired hemolytic anemia, congenital anemia, anemia of chronic diseases, colorectal cancer, kidney cancer, pancreatic cancer, breast cancer, lung cancer, esophageal cancer, melanoma, lymphoma, glioblastoma, or multiple myeloma. L'invention concerne un composé contenant une structure bis(azanylylidène) sulfonyle de formule (I) utilisé en tant qu'agoniste de PKR et/ou inhibiteur de USP9X, qui peut être utilisé pour traiter des maladies associées médiées et régulées par PKR et USP9X, les maladies associées comprenant, mais sans s'y limiter