BIOMARKERS FOR PREDICTING RESPONSIVENESS TO MEK INHIBITOR MONOTHERAPY AND COMBINATION THERAPY

• Main Authors: WINSLOW, Monte, PETROV, Dmitri, WALL, Gregory, ROSEN, Michael, WINTERS, Ian, JUAN, Joseph
• Format: Patent
• Language: English; French
• Published: 24.08.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

The invention provides compositions and methods comprising biomarker genes for identifying subjects that will respond to human MAP kinase kinase (MEK) inhibitor therapies, compositions and methods comprising biomarker genes for identifying subjects that will respond to MEK inhibitor/ target of rapamycin complex (TORC) inhibitor combination therapies, and compositions and methods comprising biomarker genes for identifying subjects that will respond to MEK inhibitor/ chemotherapy combination therapies. L'invention concerne des compositions et des méthodes comprenant des gènes biomarqueurs pour identifier des sujets qui répondront à des thérapies par inhibiteur de kinase MAP (MEK) humaine, des compositions et des méthodes comprenant des gènes biomarqueurs pour identifier des sujets qui répondront à un inhibiteur MEK/cible de polythérapies inhibitrices de complexe de rapamycine (TORC), et des compositions et des méthoes comprenant des gènes biomarqueurs pour identifier des sujets qui répondront à des polythérapies inhibiteur MEK/chimiothérapie.