PRODRUGS FOR COMPOUNDS SPECIFIC TO GRANZYME B AND USES THEREOF

Compounds of Formula (I) and Formula (II), which are capable of binding to granzyme B. Also provided herein are pharmaceutical compositions comprising such for use in, for example, imaging Granzyme B and/or treating immunoregulatory abnormalities. La présente invention concerne des composés de formu...

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Bibliographic Details
Main Authors XIONG, Hui, BILCER, Geoffrey Malcolm, HORCHLER, Carey, LIEBERMAN, Brian, HUANG, Xuan, ZHANG, Juntian, CASTANARES, Mark A, ZHANG, Wei
Format Patent
LanguageEnglish
French
Published 15.06.2023
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Compounds of Formula (I) and Formula (II), which are capable of binding to granzyme B. Also provided herein are pharmaceutical compositions comprising such for use in, for example, imaging Granzyme B and/or treating immunoregulatory abnormalities. La présente invention concerne des composés de formule (I) et de formule (II) qui sont aptes à se lier au granzyme B. L'invention concerne également des compositions pharmaceutiques comprenant de tels composés destinées à être utilisés, par exemple, dans l'imagerie de granzyme B et/ou le traitement d'anomalies immunorégulatrices.
Bibliography:Application Number: WO2022US81125