METHOD AND APPARATUS FOR STERILE AND NONINVASIVE MEASUREMENTS OF SUBSTANCES IN BIOREACTORS AND OTHER STERILE ENVIRONMENTS

The present invention provides for systems and method for noninvasive measurement and monitoring of cell culture parameters including dissolved oxygen (DO), dissolved carbon dioxide (DCO2), and pH wherein there is no direct contact with the cell culture environment which is achieved by conducting th...

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Bibliographic Details
Main Authors RAO, Govind, KUMAR, Vikash, TOLOSA, Michael, RAHMATNEJAD, Vida, GE, Xudong
Format Patent
LanguageEnglish
French
Published 15.06.2023
Subjects
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
SPIRITS
VINEGAR
WINE
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Summary:The present invention provides for systems and method for noninvasive measurement and monitoring of cell culture parameters including dissolved oxygen (DO), dissolved carbon dioxide (DCO2), and pH wherein there is no direct contact with the cell culture environment which is achieved by conducting the measurements and monitoring on the outside of the bioreactor through semi-permeable membranes incorporated into the system to enhance the process and eliminate the risk of contamination associated with invasive sensors. La présente invention concerne des systèmes et des procédés de mesure et de suivi non invasifs de paramètres de culture cellulaire, notamment l'oxygène dissous (DO), le dioxyde de carbone dissous (DCO2) et le pH, sans contact direct avec l'environnement de culture cellulaire. Les mesures et le suivi sont effectués à l'extérieur du bioréacteur, à travers des membranes semi-perméables incorporées au système, afin d'améliorer le processus et d'éliminer le risque de contamination associé aux capteurs invasifs.
Bibliography:Application Number: WO2022US80899