NOVEL ADIPONECTIN-DERIVED PEPTOID DERIVATIVE AND USE THEREOF

• Main Authors: KWAK, Yoon Na, CHOI, Myeong A, JUNG, Go Ni, MIN, Ju Sik, KIM, Eun Ju, PARK, Sun You, SUH, Joong Heon, LEE, Ji Hoon, LEE, Ha Yeon, CHUNG, Jin Ho
• Format: Patent
• Language: English; French; Korean
• Published: 15.06.2023
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS

The present invention relates to a novel peptoid derivative and the like. The peptoid derivative is obtained by partially modifying an adiponectin receptor peptide, and has high stability and excellent p-AMPK activity, compared to existing adiponectin receptor peptides and has improved physical properties and activity, thus having the advantage of being suitable for drug formulation. Therefore, the peptoid derivative of the present invention can be used for the prevention or treatment of skin inflammatory diseases, wounds, hair loss, fibrosis, metabolic diseases, or cancer, or the prevention or amelioration of aging, sensitive skin, wrinkles, or moisturization. La présente invention concerne un nouveau dérivé peptoïde et similaire. Le dérivé peptoïde est obtenu par modification partielle d'un peptide récepteur de l'adiponectine, et présente une grande stabilité et une excellente activité p-AMPK, par rapport aux peptides récepteurs de l'adiponectine existants, ainsi que des propriétés physiques et une activité améliorées, ce qui présente l'avantage de convenir à la formulation pharmaceutique. Par conséquent, le dérivé peptoïde de la présente invention peut être utilisé pour la prévention ou le traitement des maladies inflammatoires de la peau, des plaies, de la perte de cheveux, de la fibrose, des maladies métaboliques ou du cancer, ou pour la prévention ou l'amélioration du vieillissement, des peaux sensibles, des rides ou de l'hydratation. 본 발명은 신규 펩토이드 유도체 등에 관한 것으로서, 상기 펩토이드 유도체는 아디포넥틴 수용체 펩타이드를 일부 변형한 것으로, 기존 아디포넥틴 수용체 펩타이드보다 더 높은 안정성 및 우수한 p-AMPK 활성을 가지고, 물성 및 활성이 개선되어 약물 제형화에 유리하다는 장점이 있다. 따라서, 본 발명의 펩토이드 유도체는 피부 염증성 질환, 상처, 탈모, 섬유화, 대사성 질환, 또는 암의 예방 또는 치료, 노화, 민감성 피부, 주름, 또는 보습의 예방 또는 개선을 위해 활용될 수 있다.