KRAS DEGRADING COMPOUNDS COMPRISING ANNULATED 2-AMINO-3-CYANO THIOPHENES

• Main Authors: FARNABY, William, MANTOULIDIS, Andreas, SARKAR, Dhruba, TRAINOR, Nicole, LITTLE, Andrew, BROEKER, Joachim, KOFINK, Christiane, WEINSTABL, Harald, SMETHURST, Christian Alan Paul, SCHMIEDEL, Martin, CUI, Jianwen, DIERS, Emelyne, ZHONG, Siying, WATERSON, Alex, MCLENNAN, Ross, CIULLI, Alessio, ZOLLMAN, David, FESIK, Stephen W, GOODWIN-TINDALL, Jake, ABBOTT, Jason, GOLLNER, Andreas, POPOW, Johannes
• Format: Patent
• Language: English; French
• Published: 08.06.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to compounds and derivatives of formula (I) which target KRAS and can be useful as agents for treatment and/or prevention of oncological diseases. La présente invention concerne des composés et des dérivés de formule (I) qui ciblent KRAS et peuvent être utiles en tant qu'agents pour le traitement et/ou la prévention de maladies oncologiques.