ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER

• Main Authors: MANTOULIDIS, Andreas, SARKAR, Dhruba, LITTLE, Andrew, PHAN, Jason, BROEKER, Joachim, SMETHURST, Christian Alan Paul, SUN, Qi, CUI, Jianwen, FUCHS, Julian, WATERSON, Alex, HERDEIS, Lorenz, FESIK, Stephen W, WUNBERG, Tobias, ABBOTT, Jason, HODGES, Tim, GOLLNER, Andreas
• Format: Patent
• Language: English; French
• Published: 08.06.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention encompasses compounds of formula (I), Formula (I) wherein R1a, R1b, R2a, R2b, Z, R3 to R5, A, p, U, V, W and L have the meanings given in the claims and specification, their use as inhibitors of mutant Ras family proteins, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases. La présente invention concerne des composés de formule (I), dans laquelle R1a, R1b, R2a, R2b, Z, R3 à R5, A, p, U, V, W et L ont les significations données dans les revendications et la description, leur utilisation en tant qu'inhibiteurs de protéines de la famille Ras mutantes, des compositions et des préparations pharmaceutiques contenant de tels composés et leur utilisation en tant que médicaments/leurs utilisations médicales, en particulier en tant qu'agents pour le traitement et/ou la prévention de maladies oncologiques.