METHOD FOR OBTAINING HIGH-SELECTIVITY B-CHIRAL BRANCHED-CHAIN CHIRAL AMINO ACID

• Main Authors: WANG, Yang, WANG, Daogong, ZHOU, Zhangtao, PHILLIS, Andrew Toroa, LUO, Fuyuan, YE, Weiping
• Format: Patent
• Language: Chinese; English; French
• Published: 08.06.2023
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

Provided is a method for obtaining a high-selectivity β-chiral branched-chain chiral amino acid. The synthetic route of the method for obtaining a high-selectivity β-chiral branched-chain chiral amino acid is: R1 is an alkyl or an aryl; R2 is an alkyl or an aryl; R3 is an alkyl; and R4 is a benzoyl or an acetyl. By using the method for preparing a β-chiral branched-chain chiral amino acid compound, a β-chiral branched-chain chiral amino acid having multiple chiral centers can be efficiently constructed in one step. Different from a traditional enzymatically catalyzed fermentation process, the present solution has better substrate generality and a lower cost, is more environmentally friendly, and can prepare various β-chiral branched-chain chiral amino acid compounds with complex structures. L'invention concerne un procédé d'obtention d'un acide aminé chiral à chaîne ramifiée β-chirale à haute sélectivité. La voie de synthèse du procédé d'obtention d'un acide aminé chiral à chaîne ramifiée β-chirale à haute sé