METHOD FOR SCREENING MDSC INHIBITOR

• Main Authors: LEE, Myong Sok, LIM, Jong Seok, LEE, A Ram, LIM, Ji Hyun
• Format: Patent
• Language: English; French; Korean
• Published: 01.06.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present invention relates to a composition comprising a microphthalmia-associated transcription factor (MITF) inhibitor as an active ingredient for inhibiting myeloid-derived suppressor cells (MDSC). Specifically, it was confirmed that an MDSC is activated in a cancer cell microenvironment to lower an immune response, and an MITF is involved in the activation of the MDSC, and the MDSC can be inhibited using the MITF inhibitor. Thus, a composition comprising the MITF inhibitor as an active ingredient can be advantageously used to alleviate a decrease in immune response caused by an MDSC and to increase an efficiency of anticancer immunotherapy. La présente invention concerne une composition comprenant un inhibiteur du facteur de transcription associé à la microphtalmie (MITF, « microphthalmia-associated transcription factor ») en tant que principe actif pour inhiber des cellules myéloïdes suppressives (MDSC, « myeloid-derived suppressor cell »). En particulier, il a été confirmé qu'une MDSC est activée dans un microenvironnement de cellule cancéreuse pour abaisser une réponse immunitaire et qu'un MITF est impliqué dans l'activation de la MDSC, la MDSC pouvant être inhibée à l'aide de l'inhibiteur de MITF. Ainsi, une composition comprenant l'inhibiteur de MITF en tant que principe actif peut être efficacement utilisée pour atténuer une diminution de la réponse immunitaire provoquée par une MDSC et pour augmenter l'efficacité d'une immunothérapie anticancéreuse. 본 발명은 MITF(microphthalmia-associated transcription factor) 억제제를 유효성분으로 함유하는 골수-유래 억제세포(myeloid-derived suppressor cells, MDSC) 저해용 조성물에 관한 것으로, 구체적으로 암세포 미세환경에서 MDSC가 활성화되어 면역반응이 저하되고, 상기 MDSC의 활성화에 MITF가 관여하며, 상기 MITF의 억제제를 이용하여 MDSC를 저해할 수 있음을 확인하였으므로, 상기 MITF 억제제를 유효성분으로 함유하는 조성물을 MDSC에 의한 면역반응 저하를 완화하고, 항암 면역치료 효율을 증대하는데 유용하게 사용할 수 있다.