EXCIPIENT COMPOUNDS FOR BIOPOLYMER FORMULATIONS

Disclosed herein are reduced viscosity liquid formulations comprising a protein, optionally a therapeutic protein or more optionally a therapeutic antibody, and excipient compounds, optionally a lyo-enhancing excipient or more optionally caffeine. Further disclosed are methods of reducing the viscos...

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Bibliographic Details
Main Authors WUTHRICH, Philip, NAIK, Subhashchandra, ZENG, Yuhong, TRAN, Timothy, MAHONEY, Robert P
Format Patent
LanguageEnglish
French
Published 25.05.2023
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Disclosed herein are reduced viscosity liquid formulations comprising a protein, optionally a therapeutic protein or more optionally a therapeutic antibody, and excipient compounds, optionally a lyo-enhancing excipient or more optionally caffeine. Further disclosed are methods of reducing the viscosity of a liquid formulation comprising a protein, methods of treatment, and methods of improving protein processing. L'invention concerne des formulations liquides à viscosité réduite comprenant une protéine, facultativement une protéine thérapeutique ou encore un anticorps thérapeutique, et des composés excipients, facultativement un excipient améliorant la lyophilisation ou encore de la caféine. L'invention concerne en outre des méthodes de réduction de la viscosité d'une formulation liquide comprenant une protéine, des méthodes de traitement et des méthodes d'amélioration du traitement des protéines.
Bibliography:Application Number: WO2022US49799