2-AMINO IMIDAZOLE DERIVATIVES

Disclosed herein are 2-amino imidazole derivatives. These compounds inhibit Protein Arginine N-Methyl Transferase 5 (PRMT5) activity. In addition to the compounds, disclosed herein are pharmaceutical compositions containing the compounds, and methods of use, such as methods of treating cancer using...

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Bibliographic Details
Main Authors LAWSON, John David, KULYK, Svitlana, SMITH, Christopher Ronald, IVETAC, Anthony
Format Patent
LanguageEnglish
French
Published 11.05.2023
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Summary:Disclosed herein are 2-amino imidazole derivatives. These compounds inhibit Protein Arginine N-Methyl Transferase 5 (PRMT5) activity. In addition to the compounds, disclosed herein are pharmaceutical compositions containing the compounds, and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention. L'invention concerne des dérivés de 2-amino-imidazole. Ces composés inhibent l'activité de la protéine arginine N-méthyl transférase 5 (PRMT5). Outre ces composés, l'invention concerne des compositions pharmaceutiques contenant lesdits composés, et des méthodes d'utilisation, telles que des méthodes de traitement du cancer faisant appel aux composés et aux compositions pharmaceutiques de la présente invention.
Bibliography:Application Number: WO2022US48973