PHARMACEUTICAL COMPOSITION COMPRISING SALMONELLA STRAIN AND IMMUNE CHECKPOINT INHIBITOR AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF CANCER

• Main Authors: MIN, Jung-Joon, YOU, Sung-Hwan, HUY, Nguyen Dinh, HONG, Yeongjin
• Format: Patent
• Language: English; French; Korean
• Published: 11.05.2023
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention pertains to a pharmaceutical composition comprising a Salmonella strain and an immune checkpoint inhibitor as active ingredients for prevention or treatment of cancer. The present invention can be advantageously used as a prophylactic or therapeutic composition that is configured to administer a bacterium and an immune checkpoint inhibitor in combination into cancer, especially, a type of resistant cancer difficult to treat with a single anticancer therapy, to remarkably inhibit the size of a tumor, thereby improving the survival rate. La présente invention concerne une composition pharmaceutique comprenant une souche de salmonelle et un inhibiteur de point de contrôle immunitaire en tant que principes actifs pour la prévention ou le traitement du cancer. La présente invention peut être avantageusement utilisée en tant que composition prophylactique ou thérapeutique conçue pour administrer conjointement une bactérie et un inhibiteur de point de contrôle immunitaire dans un cancer, en particulier, dans un type de cancer résistant difficile à traiter avec une seule thérapie anticancéreuse, afin d'inhiber considérablement la taille d'une tumeur, ce qui permet d'améliorer le taux de survie. 본 발명은 살모넬라 균주 및 면역관문억제제를 유효성분으로 포함하는 암의 예방 또는 치료용 약학조성물에 관한 것이다. 본 발명은 암, 특히 내성 및 단일 항암요법으로 치료가 어려운 암종에 있어서, 박테리아와 면역관문억제제를 병용 투여하여, 종양의 크기를 현저히 억제함으로써, 생존률을 개선하는 예방 또는 치료제 조성물로 유용하게 이용될 수 있다.