COMPOSITION FOR TREATING OR PREVENTING CANCER

• Main Authors: KIM, Sarang, KIM, Dong Hyeon, SHIN, Yoori, LEE, Bo Eun, KIM, Jihyo
• Format: Patent
• Language: English; French; Korean
• Published: 27.04.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a composition comprising an inhibitor of herpesvirus entry mediator (HVEM) or its ligand and a heat shock protein (HSP) inhibitor for treating or preventing cancer. The use of an inhibitor of HVEM or its ligand and an HSP inhibitor in combination exhibits a synergistic effect on anticancer activity, compared to the use thereof singly, and shows an effect within as fast as 72 hours after administration. Therefore, the use of an inhibitor of HVEM or its ligand and an HSP inhibitor in combination can be advantageously utilized for preventing or treating cancer. La présente invention concerne une composition comprenant un inhibiteur du médiateur d'entrée des herpèsvirus (HVEM) ou son ligand et un inhibiteur de la protéine de choc thermique (HSP) pour le traitement ou la prévention du cancer. L'utilisation d'un inhibiteur de HVEM ou de son ligand et d'un inhibiteur de HSP en combinaison présente un effet synergique sur l'activité anticancéreuse, par rapport à l'utilisation de ceux-ci seuls, et présente un effet en seulement 72 heures après l'administration. Par conséquent, l'utilisation d'un Inhibiteur de HVEM ou de son ligand et d'un inhibiteur de HSP en combinaison peut être avantageusement utilisée pour prévenir ou traiter le cancer. 본 발명은 HVEM (Herpesvirus entry mediator) 또는 이의 리간드(ligand)의 저해제, 및 HSP (Heat shock protein) 저해제를 포함하는, 암 치료 또는 예방용 조성물에 관한 것이다. HVEM 또는 이의 리간드의 저해제, 및 HSP 저해제의 병용은 이를 단독으로 사용하는 것에 비하여 항암 활성에 대해 시너지 효과를 나타내며, 투여 72시간 내의 빠른 시간 안에 효과를 나타낸다. 따라서, 상기 HVEM 또는 이의 리간드의 저해제, 및 HSP 저해제의 병용은 암의 예방 또는 치료에 유용하게 활용될 수 있다.