SITE-SPECIFIC GLYCOPROTEIN CONJUGATES AND METHODS FOR MAKING THE SAME

The present disclosure provides a protein conjugate, comprising a protein and an oligosaccharide, wherein the oligosaccharide comprises Formula (1) : wherein, the GlcNAc is directly or indirectly linked to an amino acid of the protein, the GalX is a substituted galactose, the Fuc in parentheses is a...

Full description

Saved in:
Bibliographic Details
Main Authors SONG, Zhentao, YANG, Yi, CHEN, Ji
Format Patent
LanguageEnglish
French
Published 27.04.2023
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:The present disclosure provides a protein conjugate, comprising a protein and an oligosaccharide, wherein the oligosaccharide comprises Formula (1) : wherein, the GlcNAc is directly or indirectly linked to an amino acid of the protein, the GalX is a substituted galactose, the Fuc in parentheses is a fucose, and b is 0 or 1, the Fuc* comprises a fucose or fucose derivative (Fuco) and a molecule of interest (MOI1). The present disclosure also provides a method for making the protein conjugate and the use of the protein conjugate in disease treatment. La présente divulgation concerne un conjugué protéique, comprenant une protéine et un oligosaccharide, l'oligosaccharide comprenant la formule (1) : dans laquelle GlcNAc est lié directement ou indirectement à un acide aminé de la protéine, GalX est un galactose substitué, Fuc entre parenthèses est un fucose, et b vaut 0 ou 1, Fuc* comprend un fucose ou un dérivé fucose (Fuco) et une molécule d'intérêt (MOI1). La présente divulgation concerne également un procédé de fabrication du conjugué protéique et l'utilisation du conjugué protéique dans un traitement de maladie.
Bibliography:Application Number: WO2021CN124891