LIPID NANOPARTICLE COMPOSITIONS FOR DELIVERING CIRCULAR POLYNUCLEOTIDES

• Main Authors: BARNES, Thomas, KAUFFMAN, Kevin, WESSELHOEFT, Robert Alexander, HORHOTA, Allen T, YANG, Junghoon, GOODMAN, Brian, BECKER, Amy M, MOTZ, Gregory
• Format: Patent
• Language: English; French
• Published: 06.04.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Disclosed herein are novel lipids that can be used in combination with other lipid components, such as helper lipids, structural lipids, and cholesterols, to form lipid nanoparticles for delivery of therapeutic agents, such as nucleic acids (e.g., circular polynucleotides), both in vitro and in vivo. L'invention concerne de nouveaux lipides qui peuvent être utilisés en combinaison avec d'autres composants lipidiques, tels que des lipides auxiliaires, des lipides structuraux et des cholestérols, pour former des nanoparticules lipidiques pour l'administration d'agents thérapeutiques, tels que des acides nucléiques (par exemple, des polynucléotides circulaires), à la fois in vitro et in vivo.