LIPID NANOPARTICLE COMPOSITIONS FOR DELIVERING CIRCULAR POLYNUCLEOTIDES

Disclosed herein are novel lipids that can be used in combination with other lipid components, such as helper lipids, structural lipids, and cholesterols, to form lipid nanoparticles for delivery of therapeutic agents, such as nucleic acids (e.g., circular polynucleotides), both in vitro and in vivo...

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Bibliographic Details
Main Authors BARNES, Thomas, KAUFFMAN, Kevin, WESSELHOEFT, Robert Alexander, HORHOTA, Allen T, YANG, Junghoon, GOODMAN, Brian, BECKER, Amy M, MOTZ, Gregory
Format Patent
LanguageEnglish
French
Published 06.04.2023
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:Disclosed herein are novel lipids that can be used in combination with other lipid components, such as helper lipids, structural lipids, and cholesterols, to form lipid nanoparticles for delivery of therapeutic agents, such as nucleic acids (e.g., circular polynucleotides), both in vitro and in vivo. L'invention concerne de nouveaux lipides qui peuvent être utilisés en combinaison avec d'autres composants lipidiques, tels que des lipides auxiliaires, des lipides structuraux et des cholestérols, pour former des nanoparticules lipidiques pour l'administration d'agents thérapeutiques, tels que des acides nucléiques (par exemple, des polynucléotides circulaires), à la fois in vitro et in vivo.
Bibliography:Application Number: WO2022US45408