PHARMACEUTICAL COMPOSITION FOR TREATING INFLAMMATORY DISEASES

• Main Authors: KIM, Soo Wan, PARK, In Kyu, ANSUJA, Mattew, SAJI, Uthaman, BAE, Eun Hui, CHOI, Hong Sang
• Format: Patent
• Language: English; French; Korean
• Published: 06.04.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a pharmaceutical composition for treating inflammatory diseases, in which hydrophobic manganese oxide is loaded on micelles so as to be stably protected in vivo thereby easily being delivered to a target site. In addition, the hydrophilic and hydrophobic regions of micelles are bonded with a ROS-cleavable linker and decomposed in response to active oxygen species at an inflammatory site, thereby efficiently releasing hydrophobic manganese oxide particles, and released hydrophobic manganese oxide can generate oxygen to change the microenvironment of the target site, thereby improving the effect of physiologically active substances loaded on the micelles. L'invention concerne une composition pharmaceutique pour le traitement de maladies inflammatoires, dans laquelle de l'oxyde de manganèse hydrophobe est chargé sur des micelles de sorte à être protégé de façon stable in vivo, et d'être ainsi administré facilement à un site cible. De plus, les régions hydrophiles et hydrophobes des micelles sont liées par un lieur clivable par ROS et décomposées en réponse à des espèces actives de l'oxygène au niveau d'un site inflammatoire, ce qui libère efficacement des particules d'oxyde de manganèse hydrophobe, l'oxyde de manganèse hydrophobe libéré pouvant générer de l'oxygène pour modifier le micro-environnement du site cible, améliorant ainsi l'effet de substances physiologiquement actives chargées sur les micelles. 본 발명은 염증성 질환 치료용 약학 조성물에 관한 것으로 소수성 산화망간이 마이셀에 담지됨으로써 생체 내에서 안정적으로 보호되어 표적 부위로의 전달이 용이하다. 또한, 마이셀의 친수성 부위와 소수성 부위가 활성산소-분해성 링커(ROS-cleavable linker)로 결합되어 염증 부위의 활성산소에 반응하여 분해됨으로써, 효율적으로 소수성 산화망간 입자를 방출할 수 있으며, 방출된 소수성 산화망간이 산소를 발생시켜 표적 부위의 미세환경을 변화시켜 마이셀에 담지된 생리활성물질의 효과를 향상시킬 수 있다.