HUMANIZED ANTI-EGFRVIII ANTIBODIES AND ANTIGEN-BINDING FRAGMENTS THEREOF

• Main Authors: JARAMILLO, Maria, MARCIL, Anne, WU, Cunle, MORENO, Maria, SULEA, Traian
• Format: Patent
• Language: English; French
• Published: 06.04.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

Antigen-binding agents such as humanized antibodies or antigen-binding fragments thereof, that specifically bind to epidermal growth factor receptor variant III (EGFRvIII) are provided. The EGFRvIII-specific humanized antibodies or antigen-binding fragments thereof may be used for the treatment of cancer. L'invention concerne des agents de liaison à l'antigène tels que des anticorps humanisés ou des fragments de liaison à l'antigène de ceux-ci, qui se lient de manière spécifique au variant III du récepteur du facteur de croissance épidermique (EGFRvIII). Les anticorps humanisés spécifiques du EGFRvIII ou des fragments de liaison à l'antigène de ceux-ci peuvent être utilisés pour traiter le cancer.