PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING CARNITINE ACYLCARNITINE CARRIER INHIBITOR AND CARNITINE OCTANOYLTRANSFERASE INHIBITOR

• Main Author: KIM, Soo Youl
• Format: Patent
• Language: English; French; Korean
• Published: 30.03.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to: a pharmaceutical composition for preventing or treating cancer, comprising a carnitine acylcarnitine carrier (CAC) inhibitor and a carnitine octanoyltransferase (COT) inhibitor; and an anticancer adjuvant. The composition of the present invention significantly reduces cancer cell growth compared to when the CAC inhibitor or the COT inhibitor is used alone, and thus can be provided as an effective anticancer agent for combined use. La présente invention concerne : une composition pharmaceutique destinée à prévenir ou traiter le cancer, comprenant un inhibiteur de la carnitine-acylcarnitine translocase (CAC) et un inhibiteur de la carnitine octanoyltransférase (COT) ; et un adjuvant anticancéreux. La composition de la présente invention réduit significativement la croissance des cellules cancéreuses par rapport à l'utilisation de l'inhibiteur de la CAC ou de l'inhibiteur de la COT seuls, et peut ainsi être fournie en tant qu'agent anticancéreux efficace dans une utilisation en association. 본 발명은 카르니틴 아실카르니틴 운반자(Carnitine Acylcarnitine Carrier: CAC) 억제제 및 카르니틴 옥타노일트랜스퍼라제 억제제(Carnitine octanoyltransferase: COT)를 포함하는 암 예방 또는 치료용 약학적 조성물, 및 항암보조제에 관한 것이다. 본 발명의 조성물은 카르니틴 아실카르니틴 운반자 억제제 또는 카르니틴 옥타노일트랜스퍼라제 억제제를 각각 단독으로 사용하는 경우에 비하여 암세포 성장을 유의적으로 감소시켰으므로, 효과적인 병용 항암제로서 제공될 수 있다.