JAK2 INHIBITORS AND METHODS OF USE THEREOF

• Main Authors: DIPIETRO, Lucian V, FRIDRICH, Cary Griffin, TAYLOR, Alexander M, BOEZIO, Alessandro, MCCLEAN, Thomas H, THOMSON, Christopher, SWETT, Rebecca Jane, MADEC, Amael, KURUKULASURIYA, Ravi, EVANS, Catherine A
• Format: Patent
• Language: English; French
• Published: 02.03.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of JAK2 enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with JAK2 signaling with the compounds and compositions of the disclosure. La présente invention concerne de nouveaux composés et des compositions pharmaceutiques de ceux-ci, et des méthodes d'inhibition de l'activité d'enzymes JAK2 avec les composés et les compositions de l'invention. La présente invention concerne en outre, mais sans s'y limiter, des méthodes de traitement de troubles associés à la signalisation JAK2 avec les composés et les compositions de l'invention.