POTASSIUM CHANNEL MODULATOR, COMPOSITION AND APPLICATION

Disclosed in the present invention is a compound having a structure shown in general formula I, or a stereoisomer thereof, a pharmaceutically acceptable salt thereof, or a solvate thereof. Further disclosed in the present invention are a composition comprising the compound, a preparation and an appl...

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Bibliographic Details
Main Authors HU, Miao, WU, Yizhe, ZHOU, Xinglu, LIU, Xingguo
Format Patent
LanguageChinese
English
French
Published 02.03.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed in the present invention is a compound having a structure shown in general formula I, or a stereoisomer thereof, a pharmaceutically acceptable salt thereof, or a solvate thereof. Further disclosed in the present invention are a composition comprising the compound, a preparation and an application. The compound of the present invention has a significant activation effect on KCNQ2/3 potassium ions, and can be used for treating diseases related to potassium channel ion flow, especially for treating central nervous system diseases. La présente invention concerne un composé ayant une structure représentée par la formule générale I, ou un stéréoisomère de celui-ci, un sel pharmaceutiquement acceptable de celui-ci ou un solvate de celui-ci. La présente invention concerne en outre une composition comprenant le composé, une préparation et une application. Le composé de la présente invention a un effet d'activation significatif sur les ions potassium KCNQ2/3 et peut être utilisé pour le traitement de maladies
Bibliography:Application Number: WO2022CN115057