NOVEL MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER OR AUTOIMMUNE DISEASES, CONTAINING SAME AS ACTIVE INGREDIENT

• Main Authors: DUGGIRALA, Krishna Babu, YUN, Mi Ran, LEE, Yujin, LEE, Kwangho, JUNG, Myoung Eun, CHOI, Gildon, CHAE, Chong Hak, CHO, Byoung Chul
• Format: Patent
• Language: English; French; Korean
• Published: 23.02.2023
• Subjects: CHEMISTRY; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The present invention relates to a novel macrocyclic compound, a preparation method therefor, and a pharmaceutical composition for preventing or treating cancer or autoimmune diseases, containing same as an active ingredient. A compound represented by chemical formula 1 disclosed in the present specification exhibits excellent cytotoxicity against cancer cells while exhibiting excellent inhibitory activity against glutaminase, and thus is expected to be useful for cancer or autoimmune diseases. La présente invention concerne un nouveau composé macrocyclique, son procédé de préparation, et une composition pharmaceutique pour la prévention ou le traitement du cancer ou de maladies auto-immunes, le contenant en tant que principe actif. Un composé représenté par la formule chimique 1 divulgué dans la présente invention présente une excellente cytotoxicité contre les cellules cancéreuses tout en présentant une excellente activité inhibitrice vis-à-vis de la glutaminase, et est donc prévu pour être utile pour le cancer ou des maladies auto-immunes. 본 발명은 신규한 마크로사이클 화합물, 이의 제조방법, 이를 유효성분으로 포함하는 암 또는 자가면역질환의 예방 또는 치료용 약학적 조성물에 관한 것으로, 본 명세서에 기재된 화학식 1로 표시되는 화합물은 글루타미네이즈에 대한 우수한 억제 활성을 나타내면서, 암세포에 대한 세포 독성이 우수하여 암 또는 자가면역질환에 유용할 것으로 기대된다.