IMPLANTABLE MEDICAL DEVICE FOR THE DELIVERY OF BISPHOSPHONATE

An implantable medical device is provided. The core includes a core polymer matrix within which is dispersed a therapeutic agent comprising one or more bisphosphonates. The core polymer matrix contains an ethylene vinyl acetate copolymer. The ethylene vinyl acetate copolymer has a vinyl acetate cont...

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Bibliographic Details
Main Authors CHEN, Karen, WILSON, Brian D, HEGDE, Sushant, HALEY, Jeffrey Charles
Format Patent
LanguageEnglish
French
Published 09.02.2023
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:An implantable medical device is provided. The core includes a core polymer matrix within which is dispersed a therapeutic agent comprising one or more bisphosphonates. The core polymer matrix contains an ethylene vinyl acetate copolymer. The ethylene vinyl acetate copolymer has a vinyl acetate content of from about 10 wt.% to about 60 wt.% and/or a melting temperature of from about 40°C to about 120°C as determined in accordance with ASTM D3418-15. L'invention concerne un dispositif médical implantable. Le noyau comprend une matrice polymère centrale à l'intérieur de laquelle est dispersé un agent thérapeutique comprenant un ou plusieurs bisphosphonates. La matrice polymère centrale contient un copolymère éthylène-acétate de vinyle. Le copolymère éthylène-acétate de vinyle a une teneur en acétate de vinyle d'environ 10 % en poids à environ 60 % en poids et/ou une température de fusion d'environ 40 °C à environ 120 °C telle que déterminée conformément à la norme ASTM D3418-15.
Bibliography:Application Number: WO2022US38795