AROMATIC ACETYLENE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF

• Main Authors: GUO, Yanghui, CHEN, Lei, WU, Chengfei, QIAN, Wenjian, CHEN, Youxi, WU, Enguo, LIAO, Weiwei, YE, Cheng, MENG, Lichen, ZHANG, Heng
• Format: Patent
• Language: Chinese; English; French
• Published: 09.02.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Disclosed in the present invention are an aromatic acetylene derivative, a preparation method therefor, a pharmaceutical composition containing the derivative, and the use of the aromatic acetylene derivative or the pharmaceutical composition thereof in medicines. Specifically, disclosed in the present invention are an aromatic acetylene derivative as represented by general formula (A-I), a preparation method therefor and a pharmaceutically acceptable salt thereof, and the use thereof as a therapeutic agent, particularly an LPXC inhibitor, wherein the definition of each substituent in the general formula (A-I) is the same as that in the description. La présente invention concerne un dérivé d'acétylène aromatique, son procédé de préparation, une composition pharmaceutique contenant le dérivé, et l'utilisation du dérivé d'acétylène aromatique ou de la composition pharmaceutique de celui-ci dans des médicaments. En particulier, la présente invention concerne un dérivé d'acétylène aromatique représenté par la for