CONTROLLED-RELEASE ORAL PREPARATION AND PREPARATION METHOD THEREFOR

• Main Authors: LU, Shao Chuan, SU, Yu De, CHUANG, Jwey Yuan
• Format: Patent
• Language: Chinese; English; French
• Published: 02.02.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

A two-layer controlled-release oral preparation, which comprises a first ingredient as a quick-release layer and a second ingredient as a controlled-release layer, wherein the first ingredient comprises a xanthine derivative, and the second ingredient comprises a xanthine derivative and an enteric excipient. No more than 35% by weight of the xanthine derivative in the second ingredient is released within 90 min after in vitro elution, and 50% or more by weight of the xanthine derivative in the second ingredient is released within 3 h after in vitro elution. Préparation orale à libération contrôlée en deux couches, qui comprend un premier ingrédient comme couche à libération rapide et un second ingrédient comme couche à libération contrôlée, le premier ingrédient comprenant un dérivé de xanthine, et le second ingrédient comprenant un dérivé de xanthine et un excipient entérique. Pas plus de 35 % en poids du dérivé de xanthine dans le second ingrédient est libéré en 90 min après l'élution in vitro, et 50 % ou p