METHODS OF TREATING MEDICAL CONDITIONS AND INHIBITING LINE1 REVERSE TRANSCRIPTASE USING A SUBSTITUTED ADENINYL-PROPYLOXY PHOSPHONIC ACID OR RELATED COMPOUND

• Main Authors: KAPELLER-LIBERMANN, Rosana, ROMERO, Donna L, BISACCHI, Gregory Stuart, ZALLER, Dennis, SAUNDERS, Oliver
• Format: Patent
• Language: English; French
• Published: 29.12.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides methods and compositions for treating medical disorders, such as cancer, and inhibiting LINE1 reverse transcriptase and/or HERV-K reverse transcriptase using a substituted adeninyl-propyloxy phosphonic acid or related compound similar to tenofovir and tenofovir prodrugs like t...