METHODS OF TREATING MEDICAL CONDITIONS AND INHIBITING LINE1 REVERSE TRANSCRIPTASE USING A SUBSTITUTED ADENINYL-PROPYLOXY PHOSPHONIC ACID OR RELATED COMPOUND

The invention provides methods and compositions for treating medical disorders, such as cancer, and inhibiting LINE1 reverse transcriptase and/or HERV-K reverse transcriptase using a substituted adeninyl-propyloxy phosphonic acid or related compound similar to tenofovir and tenofovir prodrugs like t...

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Bibliographic Details
Main Authors KAPELLER-LIBERMANN, Rosana, ROMERO, Donna L, BISACCHI, Gregory Stuart, ZALLER, Dennis, SAUNDERS, Oliver
Format Patent
LanguageEnglish
French
Published 29.12.2022
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention provides methods and compositions for treating medical disorders, such as cancer, and inhibiting LINE1 reverse transcriptase and/or HERV-K reverse transcriptase using a substituted adeninyl-propyloxy phosphonic acid or related compound similar to tenofovir and tenofovir prodrugs like tenofovir alafenamide, tenofovir disoproxil fumarate, or tenofovir exalidex. L'invention concerne des procédés et des compositions pour le traitement de troubles médicaux, tels que le cancer, et l'inhibition de la transcriptase inverse LINE1 et/ou de la transcriptase inverse HERV-K à l'aide d'un acide adéninyl-propyloxy phosphonique substitué ou d'un composé apparenté similaire au ténofovir et à des promédicaments de ténofovir tels que le ténofovir alafénamide, le fumarate de ténofovir disoproxil ou le ténofovir exalidex.
Bibliography:Application Number: WO2022US34605