AURKA SELECTIVE DEGRADATION INDUCING COMPOUND

• Main Authors: JEONG, Ha Na, JO, Seung Hyun, RYU, Soo Hee, MIN, Im Suk, KIM, Seong Hoon, KIM, Chan Ho, LEE, Jun Kyu, PARK, Jung Chul
• Format: Patent
• Language: English; French; Korean
• Published: 29.12.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a novel compound that induces selective degradation of AURKA, and specifically provides a bifunctional compound in which an AURKA binding moiety and an E3 ubiquitin ligase binding moiety are linked by a chemical linker, a method for preparing same, and a use thereof. In addition, the compound according to the present invention can be effectively used for the prevention or treatment of AURKA-related diseases. La présente invention concerne un nouveau composé qui induit une dégradation sélective de l'AURKA, et concerne en particulier un composé bifonctionnel dans lequel une fraction de liaison à AURKA et une fraction de liaison à l'ubiquitine ligase E3 sont liées par un lieur chimique, son procédé de préparation et son utilisation. De plus, le composé selon la présente invention peut être utilisé efficacement pour la prévention ou le traitement de maladies associées à AURKA. 본 발명은 AURKA의 선택적 분해를 유도하는 신규 화합물에 관한 것으로, 구체적으로 AURKA 결합 모이어티와 E3 유비퀴틴 라이게이즈 결합 모이어티가 화학적 링커로 연결된 이기능성 화합물, 이의 제조방법, 및 이의 용도를 제공한다. 또한, 본 발명에 따른 화합물들은 AURKA 관련 질환의 예방 또는 치료에 유용하게 사용될 수 있다.