METHOD FOR PREDICTING RELATIONSHIP BETWEEN GENE AND TRANSCRIPTIONAL ELEMENT AND APPARATUS THEREFOR

• Main Authors: KIM, Yi Rang, GU, Changdai
• Format: Patent
• Language: English; French; Korean
• Published: 22.12.2022
• Subjects: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATIONTECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING ORPROCESSING OF MEDICAL OR HEALTHCARE DATA; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; PHYSICS

Provided are a method for predicting relationship between a gene and a transcriptional element and an apparatus therefor. A method for predicting relationship between a gene and a transcriptional element according to some embodiments of the present disclosure may comprise the steps of: setting, as an objective function, a function for minimizing the prediction error of a mathematical model that predicts a change in the expression level of a gene on the basis of the degree of influence of the transcriptional element on the gene; and calculating a value of a determinant variable to minimize the value of the objective function by using the measurement data on the change in the expression level of the gene. L'invention concerne un procédé de prédiction de la relation entre un gène et un élément transcriptionnel, et un appareil associé. Un procédé de prédiction de la relation entre un gène et un élément transcriptionnel selon certains modes de réalisation de la présente invention peut comprendre les étapes consistant à : mettre en place, en tant que fonction objective, une fonction pour minimiser l'erreur de prédiction d'un modèle mathématique qui prédit un changement du niveau d'expression d'un gène sur la base du degré d'influence de l'élément transcriptionnel sur le gène ; et calculer une valeur d'une variable déterminante pour minimiser la valeur de la fonction objective à l'aide des données de mesure sur le changement du niveau d'expression du gène. 유전자와 전사인자의 관계를 예측하는 방법 및 그 장치가 제공된다. 본 개시의 몇몇 실시예들에 따른 유전자와 전사인자의 관계를 예측하는 방법은 유전자에 대한 전사인자의 영향도를 기초로 유전자의 발현량 변화를 예측하는 수학적 모델의 예측 오차를 최소화하기 위한 함수를 목적함수로 설정하는 단계 및 유전자의 발현량 변화에 대한 측정데이터를 이용하여 목적함수의 값을 최소화하기 위한 결정변수의 값을 산출하는 단계를 포함할 수 있다.