TRAP1 INHIBITOR AND USE THEREOF

• Main Authors: KIM, So-Yeon, YOON, Nam Gu, KANG, Byoung Heon
• Format: Patent
• Language: English; French; Korean
• Published: 22.12.2022
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present specification provides a compound that inhibits TRAP1 or a pharmaceutically acceptable salt thereof. In this case, the compound or the pharmaceutically acceptable salt thereof can inhibit the binding between TRAP1 and the client protein. In addition, the present specification provides: a pharmaceutical composition for the treatment of cancer or ophthalmic disease comprising a compound that inhibits TRAP1 or a pharmaceutically acceptable salt thereof; and use thereof. La présente invention concerne un composé qui inhibe TRAP1 ou un sel pharmaceutiquement acceptable de celui-ci. Dans ce cas, le composé ou son sel pharmaceutiquement acceptable peut inhiber la liaison entre TRAP1 et la protéine client. De plus, la présente invention concerne : une composition pharmaceutique pour le traitement du cancer ou d'une maladie ophtalmique comprenant un composé qui inhibe TRAP1 ou un sel pharmaceutiquement acceptable de celui-ci ; et une utilisation associée. 본 명세서는 TRAP1을 억제하는 화합물 또는 이의 약학적으로 허용가능한 염을 제공한다. 이때, 상기 화합물 또는 이의 약학적으로 허용가능한 염은 TRAP1과 클라이언트 단백질의 결합을 억제할 수 있다. 또한, 본 명세서는 TRAP1을 억제하는 화합물 또는 이의 약학적으로 허용가능한 염을 포함하는 암 또는 안과질환 치료용 약학적 조성물 및 이의 용도를 제공한다.