EXOSOME-RICH CULTURE MEDIUM OF IMMORTALIZED STEM CELLS AND FUNCTIONAL COMPOSITION COMPRISING BOTULINUM TOXIN

• Main Authors: CHOI, Ehn Kyoung, KIM, Yun Bae, KIM, Tae Myoung
• Format: Patent
• Language: English; French; Korean
• Published: 22.12.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS; SPIRITS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES; VINEGAR; WINE

The present invention relates to an exosome-rich culture medium of immortalized stem cells and a functional composition comprising botulinum toxin. Specifically, the functional composition according to the present invention inhibits the decomposition of collagen and elastin and at the same time promotes the synthesis thereof, improves wrinkles, and promotes cell regeneration, and thus can be usefully used as a functional material for wrinkle improvement, skin regeneration, skin elasticity improvement, skin aging inhibition, or wrinkle prevention, or for wound treatment. La présente invention concerne un milieu de culture riche en exosomes de cellules souches immortalisées et une composition fonctionnelle comprenant de la toxine botulique. En particulier, la composition fonctionnelle selon la présente invention inhibe la décomposition du collagène et de l'élastine et favorise en même temps leur synthèse, améliore les rides, et favorise la régénération cellulaire, et peut donc être utilisée utilement en tant que matériau fonctionnel pour l'amélioration des rides, la régénération de la peau, l'amélioration de l'élasticité de la peau, l'inhibition du vieillissement de la peau, la prévention des rides, ou pour le traitement des plaies. 본 발명은 불멸화 줄기세포의 엑소좀 풍부 배양액 및 보툴리눔 독소를 포함하는 기능성 조성물에 관한 것이다. 구체적으로, 본 발명에 따른 기능성 조성물은 콜라겐 및 엘라스틴의 분해를 억제하는 동시에 합성을 촉진하고, 주름을 개선시키며, 세포의 재생을 촉진함으로써, 주름개선, 피부재생, 피부탄력 개선, 피부노화 억제 및 주름발생 억제 등을 위한 기능성 소재나 창상 치료 용도에 유용하게 사용될 수 있다.