PARTICLE DELIVERY SYSTEMS

Provided herein are delivery particle systems (XDP) useful for the delivery of payloads of any type. In some embodiments, a XDP particle system with tropism for target cells of interest is used to deliver CRISPR/Cas polypeptides (e.g., CasX proteins) and guide nucleic acids (gNA), for the modificati...

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Main Authors STAAHL, Brett T, GOMBERG, Trent, DENNY, Sarah, GARDNER, Matthew, MAKHIJA, Suraj, VIJAYAKUMAR, Gayathri, SIDORE, Angus, COLIN, Isabel, SPINNER, Hannah, ADIL, Maroof, FERNANDES, Jason, HIGGINS, Sean, OAKES, Benjamin
Format Patent
LanguageEnglish
French
Published 15.12.2022
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:Provided herein are delivery particle systems (XDP) useful for the delivery of payloads of any type. In some embodiments, a XDP particle system with tropism for target cells of interest is used to deliver CRISPR/Cas polypeptides (e.g., CasX proteins) and guide nucleic acids (gNA), for the modification of nucleic acids in target cells. Also provided are methods of making and using such XDP to modify the nucleic acids in such cells. L'invention concerne des systèmes d'administration de particules (XDP) utiles pour l'administration de charges utiles de tout type. Dans certains modes de réalisation, un système de particules XDP ayant un tropisme pour des cellules cibles d'intérêt est utilisé pour administrer des polypeptides CRISPR/Cas (par exemple, des protéines CasX) et des acides nucléiques de guidage (gNA), pour la modification d'acides nucléiques dans des cellules cibles. L'invention concerne également des procédés de fabrication et des méthodes d'utilisation d'un tel XDP pour modifier les acides nucléiques dans de telles cellules.
Bibliography:Application Number: WO2022US32579