NLRP3 INFLAMMASOME INHIBITOR AND APPLICATION THEREOF

• Main Authors: LI, Lin, WU, Frank
• Format: Patent
• Language: Chinese; English; French
• Published: 08.12.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to the technical field of medicine, and relates to an NLRP3 inflammasome inhibitor and an application thereof. The present invention particularly relates to a compound represented by general formula (I) or a pharmaceutically acceptable salt, a stereoisomer, or a tautomer thereof. The definitions of different groups are as defined in the description. Research shows that the compound represented by general formula (I) or the pharmaceutically acceptable salt, the stereoisomer, or the tautomer thereof has high biological activity on an NLRP3 inflammasome and has a significant clinical development value for the treatment of NLRP3-related diseases. La présente invention relève du domaine technique de la médecine, et concerne un inhibiteur de l'inflammasome NLRP3 et son utilisation. La présente invention concerne en particulier un composé représenté par la formule générale (I) ou un sel pharmaceutiquement acceptable, un stéréoisomère ou un tautomère de celui-ci. Les définitions des diff