NOVEL AAV SEROTYPES DERIVED FROM A LIBRARY SCREEN

In various embodiments, AAV serotypes capable of transducing skeletal muscle fibers and skeletal muscle stem cells (MuSC) with reduced off target tissue tropism are provided. Dans divers modes de réalisation, des sérotypes de VAA pouvant transduire des fibres de muscle squelettique et des cellules s...

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Bibliographic Details
Main Authors EMAMI, Michael R, SPENCER, Melissa J, YOUNG, Courtney S, KOHN, Donald B, PYLE, April D
Format Patent
LanguageEnglish
French
Published 22.12.2022
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:In various embodiments, AAV serotypes capable of transducing skeletal muscle fibers and skeletal muscle stem cells (MuSC) with reduced off target tissue tropism are provided. Dans divers modes de réalisation, des sérotypes de VAA pouvant transduire des fibres de muscle squelettique et des cellules souches de muscle squelettique (MuSC) avec un tropisme tissulaire hors cible réduit sont décrits.
Bibliography:Application Number: WO2022US27919